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PHLPP2 is a phosphatase that switches AKT off; it is lost in most colorectal cancers, which leaves the survival pathway on. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Protein phosphatase that dephosphorylates Ser-473 of AKT1 and hydrophobic-motif sites of PKC isoforms; expression lost or significantly decreased in about 80 percent of tested colorectal tumours at the protein level (UniProt Q6ZVD8).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
The resistance atlas has no route that names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"PHLPP2" OR ABSTRACT:"PHLPP2" OR TITLE:"PH domain and leucine rich repeat protein phosphatase 2" OR ABSTRACT:"PH domain and leucine rich repeat protein phosphatase 2" OR TITLE:"PHLPPL" OR ABSTRACT:"PHLPPL" OR TITLE:"PPM3B" OR ABSTRACT:"PPM3B") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PHLPP2, not a curated reading list.
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/phlpp2.json. Licence CC BY-NC 4.0.