PLCG1
PLCG1 (1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Sarcomas, Renal cell carcinoma, Non-Hodgkin lymphoma and 5 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signalling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganisation and cell migration. Guanine nucleotide exchange factor that binds the GTPase DNM1 and catalyses the dissociation of GDP, allowing a GTP molecule to bind in its place, therefore enhancing DNM1-dependent endocytosis. Location: Cell projection, lamellipodium; Cell projection, ruffle (UniProt). Locus 20q12 (HGNC).
- Sarcomas: Open Targets association 0.58 with sarcoma (MONDO_0005089); IntOGen driver in 1 cohort (SOFT_TISSUE)
- Renal cell carcinoma: IntOGen driver in 1 cohort (RCC)
- Non-Hodgkin lymphoma: Open Targets association 0.56 with non-Hodgkin lymphoma (MONDO_0018908)
- Skin cancer: Open Targets association 0.55 with skin cancer (MONDO_0002898)
- Leukaemia: Open Targets association 0.52 with leukaemia (MONDO_0005059)
- Gastric & gastro-oesophageal junction cancer: Open Targets association 0.50 with gastric cancer (MONDO_0001056)
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"PLCG1" OR ABSTRACT:"PLCG1" OR TITLE:"phospholipase C gamma 1" OR ABSTRACT:"phospholipase C gamma 1" OR TITLE:"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1" OR ABSTRACT:"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1" OR TITLE:"PLC148" OR ABSTRACT:"PLC148" OR TITLE:"PLC-II" OR ABSTRACT:"PLC-II" OR TITLE:"PLCgamma1" OR ABSTRACT:"PLCgamma1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PLCG1, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/plcg1.json. Licence CC BY-NC 4.0.