PTPN6
PTPN6 (Tyrosine-protein phosphatase non-receptor type 6) is an enzyme. The public catalogues list it as an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Hepatocellular carcinoma, Diffuse large B-cell lymphoma and Melanoma. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
Tyrosine phosphatase enzyme that plays important roles in controlling immune signalling pathways and fundamental physiological processes such as haematopoiesis. Dephosphorylates and negatively regulate several receptor tyrosine kinases (RTKs) such as EGFR, PDGFR and FGFR, thereby modulating their signalling activities. When recruited to immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing receptors such as immunoglobulin-like transcript 2/LILRB1, programmed cell death protein 1/PDCD1, CD3D, CD22, CLEC12A and other receptors involved in immune regulation, initiates their dephosphorylation and subsequently inhibits downstream signalling events. Modulates the signalling of several cytokine receptors including IL-4 receptor. Additionally, targets multiple cytoplasmic signalling molecules including STING1, LCK or STAT1 among others involved in diverse cellular processes including modulation of T-cell activation or cGAS-STING signalling. Within the nucleus, negatively regulates the activity of some transcription factors such as NFAT5 via direct dephosphorylation. Location: Cytoplasm; Nucleus (UniProt). Locus 12p13.31 (HGNC).
- Hepatocellular carcinoma: CIViC evidence names this disease
- Diffuse large B-cell lymphoma: IntOGen driver in 2 cohorts (DLBCLNOS)
- Melanoma: IntOGen driver in 1 cohort (MEL)
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"PTPN6" OR ABSTRACT:"PTPN6" OR TITLE:"protein tyrosine phosphatase non-receptor type 6" OR ABSTRACT:"protein tyrosine phosphatase non-receptor type 6" OR TITLE:"Tyrosine-protein phosphatase non-receptor type 6" OR ABSTRACT:"Tyrosine-protein phosphatase non-receptor type 6" OR TITLE:"PTP-1C" OR ABSTRACT:"PTP-1C" OR TITLE:"SHP-1" OR ABSTRACT:"SHP-1" OR TITLE:"SHP1" OR ABSTRACT:"SHP1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PTPN6, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/ptpn6.json. Licence CC BY-NC 4.0.