PTPRT
PTPRT (Receptor-type tyrosine-protein phosphatase T) is an enzyme. The public catalogues list it as a drug target, an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Head and neck squamous cell carcinoma, Oesophageal cancer, Gastric & gastro-oesophageal junction cancer and 5 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
May be involved in both signal transduction and cellular adhesion in the CNS. Location: Membrane (UniProt). Locus 20q12-q13.11 (HGNC).
- Head and neck squamous cell carcinoma: CIViC evidence names this disease; IntOGen driver in 1 cohort (HNSC)
- Oesophageal cancer: Open Targets association 0.54 with oesophageal cancer (MONDO_0007576); IntOGen driver in 2 cohorts (ESCA)
- Gastric & gastro-oesophageal junction cancer: Open Targets association 0.54 with gastric cancer (MONDO_0001056); IntOGen driver in 1 cohort (STAD)
- Ovarian cancer: Open Targets association 0.50 with ovarian cancer (MONDO_0008170); IntOGen driver in 1 cohort (OVT)
- Hepatocellular carcinoma: IntOGen driver in 1 cohort (HCC)
- Pancreatic ductal adenocarcinoma: IntOGen driver in 1 cohort (PAAD)
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"PTPRT" OR ABSTRACT:"PTPRT" OR TITLE:"protein tyrosine phosphatase receptor type T" OR ABSTRACT:"protein tyrosine phosphatase receptor type T" OR TITLE:"Receptor-type tyrosine-protein phosphatase T" OR ABSTRACT:"Receptor-type tyrosine-protein phosphatase T" OR TITLE:"RPTPrho" OR ABSTRACT:"RPTPrho" OR TITLE:"KIAA0283" OR ABSTRACT:"KIAA0283") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PTPRT, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/ptprt.json. Licence CC BY-NC 4.0.