RANBP2
RANBP2 (E3 SUMO-protein ligase RanBP2) is an enzyme. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Lung cancer, Hepatocellular carcinoma, Renal cell carcinoma and 5 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Binds single-stranded RNA (in vitro). May bind DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1. Location: Nucleus; Nucleus membrane; Nucleus, nuclear pore complex; Nucleus envelope (UniProt). Locus 2q13 (HGNC).
- Lung cancer: Open Targets association 0.59 with lung cancer (MONDO_0008903)
- Hepatocellular carcinoma: IntOGen driver in 2 cohorts (HCC)
- Renal cell carcinoma: IntOGen driver in 1 cohort (CCRCC)
- Pheochromocytoma and paraganglioma: IntOGen driver in 1 cohort (PGNG)
- Skin cancer: Open Targets association 0.55 with skin cancer (MONDO_0002898)
- Breast cancer: Open Targets association 0.52 with breast cancer (MONDO_0007254)
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"RANBP2" OR ABSTRACT:"RANBP2" OR TITLE:"RAN binding protein 2" OR ABSTRACT:"RAN binding protein 2" OR TITLE:"E3 SUMO-protein ligase RanBP2" OR ABSTRACT:"E3 SUMO-protein ligase RanBP2" OR TITLE:"NUP358" OR ABSTRACT:"NUP358" OR TITLE:"ADANE" OR ABSTRACT:"ADANE" OR TITLE:"ANE1" OR ABSTRACT:"ANE1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RANBP2, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/ranbp2.json. Licence CC BY-NC 4.0.