RNF43
RNF43 (E3 ubiquitin-protein ligase RNF43) is an enzyme. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Pancreatic ductal adenocarcinoma, Colorectal cancer, Gastric & gastro-oesophageal junction cancer and 5 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signalling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signalling pathway. Along with RSPO2 and ZNRF3, constitutes a master switch that governs limb specification. Location: Cell membrane; Endoplasmic reticulum membrane; Nucleus envelope (UniProt). Locus 17q22 (HGNC).
- Pancreatic ductal adenocarcinoma: IntOGen driver in 7 cohorts (PAAD, PANCREAS)
- Colorectal cancer: Open Targets association 0.65 with colorectal cancer (MONDO_0005575); IntOGen driver in 3 cohorts (COAD, COADREAD)
- Gastric & gastro-oesophageal junction cancer: Open Targets association 0.63 with gastric cancer (MONDO_0001056); IntOGen driver in 2 cohorts (STAD)
- Prostate cancer: Open Targets association 0.55 with prostate cancer (MONDO_0008315); IntOGen driver in 3 cohorts (PRAD, PROSTATE)
- Oesophageal cancer: IntOGen driver in 2 cohorts (ESCA)
- Ovarian cancer: Open Targets association 0.51 with ovarian cancer (MONDO_0008170); IntOGen driver in 1 cohort (OVT)
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"RNF43" OR ABSTRACT:"RNF43" OR TITLE:"ring finger protein 43" OR ABSTRACT:"ring finger protein 43" OR TITLE:"E3 ubiquitin-protein ligase RNF43" OR ABSTRACT:"E3 ubiquitin-protein ligase RNF43" OR TITLE:"FLJ20315" OR ABSTRACT:"FLJ20315" OR TITLE:"RNF124" OR ABSTRACT:"RNF124" OR TITLE:"DKFZp781H0392" OR ABSTRACT:"DKFZp781H0392") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RNF43, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/rnf43.json. Licence CC BY-NC 4.0.