RRM2 (Ribonucleoside-diphosphate reductase subunit M2) is an enzyme. The public catalogues list it as a drug target and a biomarker, and an approved or late-stage drug is recorded against it. Tied to Lung cancer, Leukaemia, Breast cancer and 5 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
Provides the precursors necessary for DNA synthesis. Catalyses the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signalling. Location: Cytoplasm; Nucleus (UniProt). Locus 2p25.1 (HGNC).
- Lung cancer: Open Targets association 0.62 with lung cancer (MONDO_0008903)
- Leukaemia: Open Targets association 0.62 with leukaemia (MONDO_0005059)
- Breast cancer: Open Targets association 0.61 with breast cancer (MONDO_0007254)
- Non-Hodgkin lymphoma: Open Targets association 0.60 with non-Hodgkin lymphoma (MONDO_0018908)
- Pancreatic ductal adenocarcinoma: CIViC evidence names this disease
- Ovarian cancer: Open Targets association 0.59 with ovarian cancer (MONDO_0008170)
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"RRM2" OR ABSTRACT:"RRM2" OR TITLE:"ribonucleotide reductase regulatory subunit M2" OR ABSTRACT:"ribonucleotide reductase regulatory subunit M2" OR TITLE:"Ribonucleoside-diphosphate reductase subunit M2" OR ABSTRACT:"Ribonucleoside-diphosphate reductase subunit M2" OR TITLE:"FLJ25102" OR ABSTRACT:"FLJ25102" OR TITLE:"C2orf48" OR ABSTRACT:"C2orf48") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RRM2, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/rrm2.json. Licence CC BY-NC 4.0.