SLX4 (Structure-specific endonuclease subunit SLX4) is a gene. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Myelodysplastic syndromes / neoplasms, Leukaemia, Myeloproliferative neoplasms and 1 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Location: Nucleus (UniProt). Locus 16p13.3 (HGNC).
- Myelodysplastic syndromes / neoplasms: Open Targets association 0.51 with myelodysplastic syndrome (MONDO_0018881)
- Leukaemia: Open Targets association 0.51 with leukaemia (MONDO_0005059)
- Myeloproliferative neoplasms: Open Targets association 0.51 with myeloproliferative neoplasm (MONDO_0020076)
- Acute myeloid leukaemia: Open Targets association 0.51 with acute myeloid leukaemia (MONDO_0018874)
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"SLX4" OR ABSTRACT:"SLX4" OR TITLE:"SLX4 structure-specific endonuclease subunit" OR ABSTRACT:"SLX4 structure-specific endonuclease subunit" OR TITLE:"Structure-specific endonuclease subunit SLX4" OR ABSTRACT:"Structure-specific endonuclease subunit SLX4" OR TITLE:"KIAA1784" OR ABSTRACT:"KIAA1784" OR TITLE:"KIAA1987" OR ABSTRACT:"KIAA1987" OR TITLE:"FANCP" OR ABSTRACT:"FANCP") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SLX4, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/slx4.json. Licence CC BY-NC 4.0.