SMARCB1
SMARCB1 is a protein that switches other genes on and off. The public catalogues list it as a drug target, an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
Core component of the BAF (hSWI/SNF) complex. This ATP-dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumour formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. Stimulates in vitro the remodeling activity of SMARCA4/BRG1/BAF190A. Involved in activation of CSF1 promoter. Location: Nucleus (UniProt). Locus 22q11.23 (HGNC).
- Sarcomas: Open Targets association 0.87 with sarcoma (MONDO_0005089)
- Neuroendocrine tumours: IntOGen driver in 1 cohort (PANET)
- Renal cell carcinoma: Open Targets association 0.55 with renal cell carcinoma (MONDO_0005086)
- Ovarian cancer: Open Targets association 0.51 with ovarian cancer (MONDO_0008170)
- Atypical teratoid/rhabdoid tumour: CIViC evidence names this disease; IntOGen driver in 1 cohort (ATRT)
- Epithelioid sarcoma: CIViC evidence names this disease
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"SMARCB1" OR ABSTRACT:"SMARCB1" OR TITLE:"SWI/SNF related BAF chromatin remodeling complex subunit B1" OR ABSTRACT:"SWI/SNF related BAF chromatin remodeling complex subunit B1" OR TITLE:"SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1" OR ABSTRACT:"SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1" OR TITLE:"BAF47" OR ABSTRACT:"BAF47" OR TITLE:"Ini1" OR ABSTRACT:"Ini1" OR TITLE:"INI-1" OR ABSTRACT:"INI-1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SMARCB1, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/smarcb1.json. Licence CC BY-NC 4.0.