SP140
SP140 (Nuclear body protein SP140) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Multiple myeloma and Mantle cell lymphoma. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body. May be involved in the pathogenesis of acute promyelocytic leukaemia and viral infection. May play a role in chromatin-mediated regulation of gene expression although it does not bind to histone H3 tails. Location: Nucleus; Nucleus, PML body; Cytoplasm (UniProt). Locus 2q37.1 (HGNC).
- Multiple myeloma: IntOGen driver in 1 cohort (PCM)
- Mantle cell lymphoma: CIViC evidence names this disease
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"SP140" OR ABSTRACT:"SP140" OR TITLE:"SP140 nuclear body protein" OR ABSTRACT:"SP140 nuclear body protein" OR TITLE:"Nuclear body protein SP140" OR ABSTRACT:"Nuclear body protein SP140" OR TITLE:"LYSP100-B" OR ABSTRACT:"LYSP100-B" OR TITLE:"LYSP100-A" OR ABSTRACT:"LYSP100-A") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SP140, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/sp140.json. Licence CC BY-NC 4.0.