TBX3 (T-box transcription factor TBX3) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer, Colorectal cancer, Skin cancer and 3 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
Transcriptional repressor involved in developmental processes. Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes. Probably plays a role in limb pattern formation. Required for mammary placode induction, and maintenance of the mammary buds during development. Involved in branching morphogenesis in both developing lungs and adult mammary glands, via negative modulation of target genes; acting redundantly with TBX2. Required, together with TBX2, to maintain cell proliferation in the embryonic lung mesenchyme; perhaps acting downstream of SHH, BMP and TGFbeta signalling. Location: Nucleus (UniProt). Locus 12q24.21 (HGNC).
- Breast cancer: Open Targets association 0.75 with breast cancer (MONDO_0007254); IntOGen driver in 5 cohorts (BRCA)
- Colorectal cancer: Open Targets association 0.62 with colorectal cancer (MONDO_0005575); IntOGen driver in 2 cohorts (COADREAD)
- Skin cancer: Open Targets association 0.59 with skin cancer (MONDO_0002898)
- Prostate cancer: Open Targets association 0.52 with prostate cancer (MONDO_0008315)
- Melanoma: Open Targets association 0.59 with melanoma (MONDO_0005105)
- Diffuse large B-cell lymphoma: IntOGen driver in 1 cohort (DLBCLNOS)
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"TBX3" OR ABSTRACT:"TBX3" OR TITLE:"T-box transcription factor 3" OR ABSTRACT:"T-box transcription factor 3" OR TITLE:"T-box transcription factor TBX3" OR ABSTRACT:"T-box transcription factor TBX3" OR TITLE:"TBX3-ISO" OR ABSTRACT:"TBX3-ISO") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TBX3, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/tbx3.json. Licence CC BY-NC 4.0.