TRIM24
TRIM24 (Transcription intermediary factor 1-alpha) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Leukaemia, Prostate cancer, Lung cancer and 3 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. During the DNA damage response, participates in an autoregulatory feedback loop with TP53. Early in response to DNA damage, ATM kinase phosphorylates TRIM24 leading to its ubiquitination and degradation. After sufficient DNA repair has occurred, TP53 activates TRIM24 transcription, ultimately leading to TRIM24-mediated TP53 ubiquitination and degradation. Location: Nucleus; Cytoplasm; Mitochondrion (UniProt). Locus 7q33-q34 (HGNC).
- Leukaemia: Open Targets association 0.60 with leukaemia (MONDO_0005059)
- Prostate cancer: IntOGen driver in 1 cohort (PRAD)
- Lung cancer: Open Targets association 0.53 with lung cancer (MONDO_0008903)
- Breast cancer: Open Targets association 0.53 with breast cancer (MONDO_0007254)
- Ovarian cancer: Open Targets association 0.51 with ovarian cancer (MONDO_0008170)
- Non-Hodgkin lymphoma: Open Targets association 0.51 with non-Hodgkin lymphoma (MONDO_0018908)
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"TRIM24" OR ABSTRACT:"TRIM24" OR TITLE:"tripartite motif containing 24" OR ABSTRACT:"tripartite motif containing 24" OR TITLE:"Transcription intermediary factor 1-alpha" OR ABSTRACT:"Transcription intermediary factor 1-alpha" OR TITLE:"hTIF1" OR ABSTRACT:"hTIF1" OR TITLE:"Tif1a" OR ABSTRACT:"Tif1a" OR TITLE:"RNF82" OR ABSTRACT:"RNF82") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TRIM24, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/trim24.json. Licence CC BY-NC 4.0.