TRRAP
TRRAP (Transformation/transcription domain-associated protein) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer, Renal cell carcinoma, Lung cancer and 5 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Also involved in transcription activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes. Probably acts by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation. Location: Nucleus (UniProt). Locus 7q22.1 (HGNC).
- Bladder & urothelial cancer: Open Targets association 0.55 with urinary bladder cancer (MONDO_0001187); IntOGen driver in 4 cohorts (BLCA)
- Renal cell carcinoma: IntOGen driver in 2 cohorts (CCRCC)
- Lung cancer: Open Targets association 0.57 with lung cancer (MONDO_0008903)
- Skin cancer: Open Targets association 0.57 with skin cancer (MONDO_0002898)
- Salivary gland cancers: IntOGen driver in 1 cohort (ACYC)
- Head and neck squamous cell carcinoma: IntOGen driver in 1 cohort (HNSC)
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"TRRAP" OR ABSTRACT:"TRRAP" OR TITLE:"transformation/transcription domain associated protein" OR ABSTRACT:"transformation/transcription domain associated protein" OR TITLE:"Transformation/transcription domain-associated protein" OR ABSTRACT:"Transformation/transcription domain-associated protein" OR TITLE:"TR-AP" OR ABSTRACT:"TR-AP" OR TITLE:"PAF400" OR ABSTRACT:"PAF400" OR TITLE:"Tra1" OR ABSTRACT:"Tra1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TRRAP, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/trrap.json. Licence CC BY-NC 4.0.