WWOX (WW domain-containing oxidoreductase) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Oesophageal cancer. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
Putative oxidoreductase. Acts as a tumour suppressor and plays a role in apoptosis. Required for normal bone development. May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signalling and TGFB1-mediated cell death. May also play a role in tumour necrosis factor (TNF)-mediated cell death. Location: Cytoplasm; Nucleus; Mitochondrion; Golgi apparatus (UniProt). Locus 16q23.1-q23.2 (HGNC).
- Oesophageal cancer: Open Targets association 0.62 with oesophageal cancer (MONDO_0007576)
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"WWOX" OR ABSTRACT:"WWOX" OR TITLE:"WW domain containing oxidoreductase" OR ABSTRACT:"WW domain containing oxidoreductase" OR TITLE:"WW domain-containing oxidoreductase" OR ABSTRACT:"WW domain-containing oxidoreductase" OR TITLE:"WOX1" OR ABSTRACT:"WOX1" OR TITLE:"SDR41C1" OR ABSTRACT:"SDR41C1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about WWOX, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/wwox.json. Licence CC BY-NC 4.0.