ZRSR2
ZRSR2 (U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Myeloproliferative neoplasms, Leukaemia, Skin cancer and 2 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
Pre-mRNA-binding protein required for splicing of both U2- and U12-type introns. Selectively interacts with the 3'-splice site of U2- and U12-type pre-mRNAs and promotes different steps in U2 and U12 intron splicing. Recruited to U12 pre-mRNAs in an ATP-dependent manner and is required for assembly of the pre-spliceosome, a precursor to other spliceosomal complexes. For U2-type introns, it is selectively and specifically required for the second step of splicing. Location: Nucleus (UniProt). Locus Xp22.2 (HGNC).
- Myeloproliferative neoplasms: Open Targets association 0.59 with myeloproliferative neoplasm (MONDO_0020076)
- Leukaemia: Open Targets association 0.57 with leukaemia (MONDO_0005059)
- Skin cancer: Open Targets association 0.52 with skin cancer (MONDO_0002898)
- Non-Hodgkin lymphoma: Open Targets association 0.51 with non-Hodgkin lymphoma (MONDO_0018908)
- Acute myeloid leukaemia: CIViC evidence names this disease; IntOGen driver in 1 cohort (AML)
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"ZRSR2" OR ABSTRACT:"ZRSR2" OR TITLE:"zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2" OR ABSTRACT:"zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2" OR TITLE:"U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2" OR ABSTRACT:"U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2" OR TITLE:"U2AF1-RS2" OR ABSTRACT:"U2AF1-RS2" OR TITLE:"ZC3H22" OR ABSTRACT:"ZC3H22" OR TITLE:"U2AF1L2" OR ABSTRACT:"U2AF1L2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ZRSR2, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/zrsr2.json. Licence CC BY-NC 4.0.