Doxifluridine
Doxifluridine is an oral fluorouracil prodrug approved in Japan in 1987 and used in China and Korea for stomach, bowel and breast cancers; capecitabine, which the body turns into doxifluridine, later carried the same idea to the rest of the world.
Overview
Doxifluridine was developed by Roche and approved in Japan in 1987 for gastric, colorectal, breast, cervical and bladder cancers, taken as daily capsules. Because it depends on thymidine phosphorylase for activation, it achieves higher fluorouracil concentrations in tumours than in normal gut, though diarrhoea remains its main toxicity. Capecitabine adds two further enzymatic steps so that doxifluridine is generated inside the body, and it displaced doxifluridine in Western development. Doxifluridine remains in use in Japan, China and South Korea, mostly in adjuvant gastric cancer regimens.
Converted to fluorouracil by thymidine phosphorylase, an enzyme more abundant in many tumours than in normal tissue; it is the final intermediate in capecitabine's activation. Connects to Thymidylate synthase (TYMS).
1.Doxifluridine slips into a pocket on Thymidylate synthase (TYMS).
Trials
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Latest papers
topQuery for this drug: (TITLE:"Doxifluridine" OR ABSTRACT:"Doxifluridine" OR TITLE:"Furtulon" OR ABSTRACT:"Furtulon" OR TITLE:"5'-Deoxy-5-fluorouridine" OR ABSTRACT:"5'-Deoxy-5-fluorouridine" OR TITLE:"5'-DFUR" OR ABSTRACT:"5'-DFUR") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Doxifluridine, not a curated reading list.
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