Altretamine
Altretamine is an oral chemotherapy tablet approved in 1990 as a single agent for ovarian cancer that has persisted or come back after platinum-based treatment, now rarely used.
Overview
Hexamethylmelamine was studied through the 1970s in ovarian, lung and cervical cancers. The FDA approved it in December 1990 for palliative treatment of persistent or recurrent ovarian cancer after first-line cisplatin or alkylating agent combinations, on response rates of roughly 15 to 20 percent in platinum-refractory disease. Nausea, peripheral neuropathy and mood changes limit dosing, and it is taken in 14- or 21-day cycles. With the arrival of paclitaxel, liposomal doxorubicin, gemcitabine and PARP inhibitors it fell to the end of the ovarian cancer sequence and has been discontinued in several countries.
Metabolised by liver cytochromes to reactive methylol intermediates that form DNA adducts; its exact alkylating chemistry differs from classic nitrogen mustards.
1.Altretamine slips into a pocket on its target.
Approvals
| Region | Year | Indication |
|---|---|---|
| US | 1990 | Persistent or recurrent ovarian cancer after first-line cisplatin or alkylating agent combinations |
Trials
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Latest papers
topQuery for this drug: (TITLE:"Altretamine" OR ABSTRACT:"Altretamine" OR TITLE:"Hexalen" OR ABSTRACT:"Hexalen" OR TITLE:"Hexamethylmelamine" OR ABSTRACT:"Hexamethylmelamine" OR TITLE:"HMM" OR ABSTRACT:"HMM") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Altretamine, not a curated reading list.
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