Mitobronitol
Mitobronitol was a Hungarian-developed oral tablet used in Europe from the 1960s to control chronic myeloid leukaemia and polycythaemia, an alternative to busulfan that disappeared once hydroxycarbamide, interferon and imatinib took over.
Overview
Mitobronitol was developed at the Hungarian company Chinoin and marketed in several European countries for chronic myeloid leukaemia in its chronic phase and for polycythaemia vera and essential thrombocythaemia, achieving haematological control comparable to busulfan with less pulmonary fibrosis. Like other alkylating agents it carried a risk of secondary leukaemia, and it was never approved in the United States. Hydroxycarbamide and interferon alfa displaced it in the 1980s and 1990s, and imatinib made chemotherapy for chronic phase disease obsolete after 2001.
A brominated mannitol that alkylates DNA after conversion to an epoxide, suppressing proliferating myeloid cells.
1.Mitobronitol slips into a pocket on its target.
Trials
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Latest papers
topQuery for this drug: (TITLE:"Mitobronitol" OR ABSTRACT:"Mitobronitol" OR TITLE:"Myelobromol" OR ABSTRACT:"Myelobromol" OR TITLE:"Dibromomannitol" OR ABSTRACT:"Dibromomannitol" OR TITLE:"DBM" OR ABSTRACT:"DBM") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Mitobronitol, not a curated reading list.
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