Pixantrone
Pixantrone is an anthracycline-like drug engineered to spare the heart, approved in the European Union in 2012 as a single agent for adults with aggressive B-cell lymphoma that has relapsed several times.
Overview
Pixantrone was granted conditional marketing authorisation in the European Union in 2012 for adults with multiply relapsed or refractory aggressive non-Hodgkin B-cell lymphoma, based on the PIX301 trial in which it produced more complete responses than other single agents. Because it lacks the anthracycline quinone, it causes less cardiotoxicity than doxorubicin in animal models, which allows treatment of patients who have already had a full lifetime dose of anthracyclines. The FDA did not approve it, and the EU authorisation remains conditional pending further confirmatory data.
A DNA intercalator and topoisomerase II poison designed to keep the antitumour activity of the anthracyclines while removing the iron-binding quinone that drives their cardiotoxicity. Connects to Topoisomerase II alpha (TOP2A).
1.Pixantrone slips into a pocket on Topoisomerase II alpha (TOP2A).
Approvals
| Region | Year | Indication |
|---|---|---|
| EU | 2012 | Multiply relapsed or refractory aggressive non-Hodgkin B-cell lymphoma, single agent (conditional) |
Trials
topTrials recruiting now
Country and place are remembered in this browser only. A postcode is sent to OpenStreetMap's Nominatim service to find coordinates when you press the button; nothing else leaves your device.
Latest papers
topQuery for this drug: (TITLE:"Pixantrone" OR ABSTRACT:"Pixantrone" OR TITLE:"Pixuvri" OR ABSTRACT:"Pixuvri" OR TITLE:"BBR 2778" OR ABSTRACT:"BBR 2778" OR TITLE:"Pixantrone dimaleate" OR ABSTRACT:"Pixantrone dimaleate") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Pixantrone, not a curated reading list.
Similar pages
not linked directly; found by shared links- TreatmentTeniposide
Shares Topoisomerase II alpha (TOP2A), Cytotoxic chemotherapy and the tag chembl-universe.
- TreatmentAmsacrine
Shares Topoisomerase II alpha (TOP2A), Cytotoxic chemotherapy and the tag chembl-universe.
- TreatmentStreptozocin
Shares Doxorubicin, Cytotoxic chemotherapy and the tag chembl-universe.
- TreatmentEthiodized oil
Shares Doxorubicin and the tag chembl-universe.
- TreatmentAltretamine
Shares Cytotoxic chemotherapy and the tag chembl-universe.
- TreatmentOlaratumab
Shares Doxorubicin and the tag chembl-universe.
- TreatmentAlitretinoin
Shares Cytotoxic chemotherapy and the tag chembl-universe.
- TreatmentPorfimer sodium
Shares Cytotoxic chemotherapy and the tag chembl-universe.