Plicamycin
Plicamycin, approved in 1970, was a chemotherapy for testicular cancer that fell out of use as cisplatin arrived, and was kept for treating dangerously high calcium levels caused by cancer until it was discontinued in 2000.
Overview
Mithramycin came from Streptomyces plicatus and was approved by the FDA in 1970 for disseminated testicular tumours not amenable to surgery or radiotherapy, and for hypercalcaemia and hypercalciuria of malignancy, where a single low dose lowered calcium within a day or two by suppressing osteoclasts. Bleeding from thrombocytopenia and platelet dysfunction and liver and kidney toxicity limited it, cisplatin-based combinations made it obsolete in germ cell tumours, and bisphosphonates replaced it for hypercalcaemia. Pfizer discontinued it in 2000. It has returned to research as a selective Sp1 inhibitor in Ewing sarcoma and other cancers.
Binds GC-rich DNA and displaces the transcription factor Sp1, silencing genes including those that drive osteoclast activity and cancer cell growth.
1.Plicamycin slips into a pocket on its target.
Approvals
| Region | Year | Indication |
|---|---|---|
| US | 1970 | Disseminated testicular tumours; hypercalcaemia and hypercalciuria of malignancy · Discontinued in 2000 |
Trials
topTrials recruiting now
Country and place are remembered in this browser only. A postcode is sent to OpenStreetMap's Nominatim service to find coordinates when you press the button; nothing else leaves your device.
Latest papers
topQuery for this drug: (TITLE:"Plicamycin" OR ABSTRACT:"Plicamycin" OR TITLE:"Mithracin" OR ABSTRACT:"Mithracin" OR TITLE:"Mithramycin" OR ABSTRACT:"Mithramycin" OR TITLE:"Aureolic acid" OR ABSTRACT:"Aureolic acid") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Plicamycin, not a curated reading list.
Similar pages
not linked directly; found by shared links- TreatmentAltretamine
Shares Cytotoxic chemotherapy and the tag chembl-universe.
- TreatmentAlitretinoin
Shares Cytotoxic chemotherapy and the tag chembl-universe.
- TreatmentPorfimer sodium
Shares Cytotoxic chemotherapy and the tag chembl-universe.
- TreatmentUracil mustard
Shares Cytotoxic chemotherapy and the tag chembl-universe.
- TreatmentEstramustine
Shares Cytotoxic chemotherapy and the tag chembl-universe.
- TreatmentFloxuridine
Shares Cytotoxic chemotherapy and the tag chembl-universe.
- TreatmentPlitidepsin
Shares Cytotoxic chemotherapy and the tag chembl-universe.
- TreatmentTeniposide
Shares Cytotoxic chemotherapy and the tag chembl-universe.