Zirconium-89 girentuximab
Zirconium-89 girentuximab is Telix's PET scan that tells whether a kidney mass is clear cell renal cell carcinoma without a biopsy; the phase 3 ZIRCON trial met its endpoints in 2023 and the product is under regulatory review.
Overview
Telix Pharmaceuticals' TLX250-CDx labels the anti-CAIX antibody girentuximab with zirconium-89. In the ZIRCON phase 3 trial of 300 patients with indeterminate renal masses, the scan identified clear cell renal cell carcinoma with high sensitivity and specificity against surgical histology. Telix filed with the FDA, which issued a refusal-to-file letter in 2024 over manufacturing information, and a resubmission followed. A further phase 3 trial is registered.
Girentuximab binds carbonic anhydrase IX, expressed by nearly all clear cell renal cell carcinomas but not by normal kidney; the zirconium-89 label shows the tumour on PET days after injection.
1.Zirconium-89 girentuximab binds its target.
Trials
topTrials recruiting now
Country and place are remembered in this browser only. A postcode is sent to OpenStreetMap's Nominatim service to find coordinates when you press the button; nothing else leaves your device.
Landmark trials
Latest papers
topQuery for this drug: (TITLE:"Zirconium-89 girentuximab" OR ABSTRACT:"Zirconium-89 girentuximab" OR TITLE:"TLX250-CDx" OR ABSTRACT:"TLX250-CDx" OR TITLE:"89Zr-DFO-girentuximab" OR ABSTRACT:"89Zr-DFO-girentuximab" OR TITLE:"Zircaix" OR ABSTRACT:"Zircaix") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Zirconium-89 girentuximab, not a curated reading list.
Similar pages
not linked directly; found by shared links- TreatmentPSMA-1007 F-18
Shares PET (positron emission tomography) and the tag pipeline.
- TreatmentAL8326
Shares Renal cell carcinoma and the tag pipeline.
- TreatmentADI-270
Shares Renal cell carcinoma and the tag pipeline.
- TreatmentFlorastamin F-18
Shares PET (positron emission tomography) and the tag pipeline.
- TreatmentTQB2450
Shares Renal cell carcinoma and the tag pipeline.
- TreatmentJK08
Shares Renal cell carcinoma and the tag pipeline.
- TreatmentAbexinostat
Shares Renal cell carcinoma and the tag pipeline.
- TreatmentIBI363
Shares Renal cell carcinoma and the tag pipeline.