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F-MISO (JBS-003) is an experimental radiopharmaceutical PET imaging agent from Juniper Biosciences, in phase 3 trials for HPV-positive oropharyngeal cancer and HPV-positive head and neck cancer.
F-MISO (JBS-003) (JBS-003, F-MISO, 18F-FMISO) is a radiopharmaceutical PET imaging agent (diagnostic) from Juniper Biosciences, with Memorial Sloan Kettering Cancer Center as partner. A fluorine-18 PET tracer that becomes trapped in oxygen-starved tumour cells; FMISO PET is used to pick out HPV-positive throat cancer patients whose tumours are not hypoxic and who may safely receive lower-dose radiation. Its furthest stage is phase 3, for HPV-positive oropharyngeal cancer and HPV-positive head and neck cancer. ClinicalTrials.gov registers it in 3 studies linked below. FDA Breakthrough Therapy designation reported by MSK (page updated September 2026). Phase 3 NCT06563479 recruiting, sponsored by Memorial Sloan Kettering. Whether it works in people has not been established unless a trial below reports it.
A fluorine-18 PET tracer that becomes trapped in oxygen-starved tumour cells; FMISO PET is used to pick out HPV-positive throat cancer patients whose tumours are not hypoxic and who may safely receive lower-dose radiation.
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Query for this drug: (TITLE:"F-MISO" OR ABSTRACT:"F-MISO" OR TITLE:"JBS-003" OR ABSTRACT:"JBS-003" OR TITLE:"18F-FMISO" OR ABSTRACT:"18F-FMISO" OR TITLE:"[18F]fluoromisonidazole" OR ABSTRACT:"[18F]fluoromisonidazole" OR TITLE:"fluorine-18 fluoromisonidazole" OR ABSTRACT:"fluorine-18 fluoromisonidazole") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about F-MISO (JBS-003), not a curated reading list.
Shares HPV-positive oropharyngeal cancer, Oropharyngeal cancer (tonsil and base of tongue) and the tag pipeline.
Shares HPV-positive oropharyngeal cancer and the tag pipeline.
Shares HPV-positive oropharyngeal cancer and the tag pipeline.
Shares HPV-positive oropharyngeal cancer and the tag pipeline.
Shares Oropharyngeal cancer (tonsil and base of tongue) and the tag pipeline.
Shares Oropharyngeal cancer (tonsil and base of tongue) and the tag pipeline.
Shares Oropharyngeal cancer (tonsil and base of tongue) and the tag pipeline.
Shares Oropharyngeal cancer (tonsil and base of tongue) and the tag pipeline.
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