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MOMA-341 is an experimental small molecule from MOMA Therapeutics, in phase 1 trials for MSI-high / dMMR solid tumours, colorectal cancer and gastric cancer and other cancers.
MOMA-341 is a small molecule (oral, covalent) from MOMA Therapeutics. An oral, potent and selective covalent inhibitor of Werner (WRN) helicase, which MSI-high and mismatch repair deficient tumour cells need to survive; tested alone and with irinotecan or immunotherapy. Its furthest stage is phase 1, for MSI-high / dMMR solid tumours, colorectal cancer, gastric cancer and endometrial cancer. ClinicalTrials.gov registers it in one study linked below. NCT06974110 recruiting (registry, checked 3 Nov 2026); first patient dosed July 2025. Whether it works in people has not been established unless a trial below reports it.
An oral, potent and selective covalent inhibitor of Werner (WRN) helicase, which MSI-high and mismatch repair deficient tumour cells need to survive; tested alone and with irinotecan or immunotherapy. Connects to WRN helicase (MSI-high cancers).
1.MOMA-341 slips into a pocket on WRN helicase (MSI-high cancers).
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Query for this drug: (TITLE:"MOMA-341" OR ABSTRACT:"MOMA-341") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MOMA-341, not a curated reading list.
Shares MOMA Therapeutics, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Endometrial cancer, Gastric & gastro-oesophageal junction cancer, Metastatic cancer (cancer that has spread), Colorectal cancer and the tag pipeline.
Shares Endometrial cancer, Gastric & gastro-oesophageal junction cancer, Colorectal cancer and the tag pipeline.
Shares MOMA Therapeutics, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Endometrial cancer, Gastric & gastro-oesophageal junction cancer, Colorectal cancer and the tag pipeline.
Shares MOMA Therapeutics, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares WRN helicase (MSI-high cancers), Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Endometrial cancer, Metastatic cancer (cancer that has spread), Colorectal cancer and the tag pipeline.
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