Singlera's methylation blood test, tested on stored samples from a Chinese cohort, that reported finding cancers up to four years before they were diagnosed; it has not been confirmed in a prospective study.
In Chen et al. (Nature Communications 2020), PanSeer was run on stored plasma from the Taizhou Longitudinal Study (123,115 healthy people who gave samples): among 605 asymptomatic people, 191 later diagnosed with stomach, oesophageal, colorectal, lung or liver cancer within four years, it detected cancer in 95% of those later diagnosed, and in 88% of post-diagnosis patients at 96% specificity. The authors state that future longitudinal studies are required to confirm the result. Singlera's website no longer lists PanSeer or another multi-cancer product (it lists single-cancer colorectal and liver tests); its FuSion (NCT05159544) and INSPIRE (NCT06440018) studies develop multi-omic and methylation-plus-fragmentomics successors. No regulatory status was found.
Targeted methylation sequencing of circulating tumour DNA for five common cancers.
1.PanSeer slips into a pocket on its target.
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Query for this drug: (TITLE:"PanSeer" OR ABSTRACT:"PanSeer") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PanSeer, not a curated reading list.
Shares Cell-free DNA methylation tests, Multi-cancer early detection (MCED), Oesophageal cancer, Liquid biopsy (ctDNA) and the tags test, mced.
Shares Cell-free DNA methylation tests, Multi-cancer early detection (MCED), Liquid biopsy (ctDNA) and the tags test, mced.
Shares Cell-free DNA methylation tests, Multi-cancer early detection (MCED), Liquid biopsy (ctDNA) and the tags test, mced.
Shares Multi-cancer early detection (MCED), Liquid biopsy (ctDNA) and the tags test, mced.
Shares Multi-cancer early detection (MCED), Liquid biopsy (ctDNA) and the tags test, mced.
Shares Cell-free DNA methylation tests, Multi-cancer early detection (MCED), Liquid biopsy (ctDNA) and the tags test, mced.
Shares Cell-free DNA methylation tests, Multi-cancer early detection (MCED), Liquid biopsy (ctDNA) and the tags test, mced.
Shares Multi-cancer early detection (MCED), Liquid biopsy (ctDNA) and the tags test, mced.
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