Technetium Tc-99m sulfur colloid
Technetium sulfur colloid is the radioactive tracer injected around a breast cancer or melanoma before surgery so the surgeon can find the first lymph node the tumour drains to and remove only that node instead of the whole basin.
Overview
Technetium-99m sulfur colloid has been used for liver, spleen and bone marrow scintigraphy since the 1970s, and the FDA label was extended to lymphatic mapping to localise lymph nodes draining a primary breast tumour or melanoma. Sentinel node biopsy guided by the tracer, often with blue dye, replaced routine axillary dissection in breast cancer and elective node dissection in melanoma after the NSABP B-32 and MSLT-I trials, sparing most patients lymphoedema. Tilmanocept (Lymphoseek), a purpose-designed mannose receptor agent, is the newer alternative.
Colloidal particles labelled with technetium-99m are taken up by macrophages; injected near a tumour they drain to and lodge in the first (sentinel) lymph nodes, which a gamma probe then finds during surgery.
1.Technetium Tc-99m sulfur colloid binds its target on the cancer cell or is taken up by it.
Trials
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Latest papers
topQuery for this drug: (TITLE:"Technetium Tc-99m sulfur colloid" OR ABSTRACT:"Technetium Tc-99m sulfur colloid" OR TITLE:"Technetium Tc 99m Sulfur Colloid Kit" OR ABSTRACT:"Technetium Tc 99m Sulfur Colloid Kit" OR TITLE:"Tc-99m sulphur colloid" OR ABSTRACT:"Tc-99m sulphur colloid") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Technetium Tc-99m sulfur colloid, not a curated reading list.
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