VS-7375
VS-7375 is an experimental small-molecule drug from Verastem in phase 2 trials for pancreatic ductal adenocarcinoma, non-small-cell lung cancer and colorectal cancer, aimed at KRAS.
Overview
VS-7375 is a small-molecule drug developed by Verastem. Its target is KRAS (the sponsor names KRAS G12D). The sponsor states: An oral KRAS G12D (ON/OFF) inhibitor. ClinicalTrials.gov describes the intervention as: VS-7375 is a highly selective oral, non-covalent, small molecule KRAS G12D (ON/OFF) inhibitor. It is the investigational product in 4 recruiting or active industry-led phase 2 and phase 3 interventional cancer trials, in pancreatic ductal adenocarcinoma, non-small-cell lung cancer and colorectal cancer. The largest, NCT07020221, plans to enrol 295 participants with primary completion expected 2028-12. Status reflects the highest phase registered on ClinicalTrials.gov at the 2026-09-11 check; no efficacy results are recorded here.
Trials
topTrials recruiting now
Country and place are remembered in this browser only. A postcode is sent to OpenStreetMap's Nominatim service to find coordinates when you press the button; nothing else leaves your device.
Latest papers
topQuery for this drug: (TITLE:"VS-7375" OR ABSTRACT:"VS-7375") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about VS-7375, not a curated reading list.
Similar pages
not linked directly; found by shared links- TreatmentJYP0015
Shares KRAS, Pancreatic ductal adenocarcinoma, Colorectal cancer, Non-small-cell lung cancer and the tags pipeline, ctgov-ingest.
- TreatmentJDQ443
Shares KRAS, Colorectal cancer, Non-small-cell lung cancer and the tags pipeline, ctgov-ingest.
- TreatmentMavrostobart
Shares Pancreatic ductal adenocarcinoma, Non-small-cell lung cancer and the tags pipeline, ctgov-ingest.
- TreatmentXNW27011
Shares Pancreatic ductal adenocarcinoma, Colorectal cancer, Non-small-cell lung cancer and the tags pipeline, ctgov-ingest.
- TreatmentSitneprotafib
Shares Pancreatic ductal adenocarcinoma, Colorectal cancer, Non-small-cell lung cancer and the tags pipeline, ctgov-ingest.
- TreatmentSetidegrasib
Shares KRAS, Pancreatic ductal adenocarcinoma, Non-small-cell lung cancer and the tags pipeline, ctgov-ingest.
- TreatmentGFH375
Shares KRAS, Pancreatic ductal adenocarcinoma, Non-small-cell lung cancer and the tags pipeline, ctgov-ingest.
- TreatmentINCB161734
Shares KRAS, Pancreatic ductal adenocarcinoma and the tags pipeline, ctgov-ingest.