Zimberelimab
Zimberelimab is a PD-1 antibody approved in China in 2021 for relapsed classical Hodgkin lymphoma, and the checkpoint partner in Arcus and Gilead's Western trials of the TIGIT antibody domvanalimab.
Overview
Guangzhou Gloria Biosciences' zimberelimab (GLS-010) received NMPA approval in 2021 for relapsed or refractory classical Hodgkin lymphoma after at least two lines of therapy, with a later cervical cancer indication. Outside China, Arcus Biosciences licensed it as AB122 and uses it as the PD-1 backbone with domvanalimab in the STAR-121 and STAR-221 phase 3 trials in lung and gastro-oesophageal cancer. A phase 3 trial in cervical cancer is registered in China.
Blocks PD-1 on T cells so tumour cells cannot switch them off through PD-L1. Connects to PD-1.
1.Zimberelimab binds PD-1.
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Approvals
| Region | Year | Indication |
|---|---|---|
| CN | 2021 | Relapsed or refractory classical Hodgkin lymphoma after two or more lines of therapy |
Trials
topTrials recruiting now
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Landmark trials
Latest papers
topQuery for this drug: (TITLE:"Zimberelimab" OR ABSTRACT:"Zimberelimab" OR TITLE:"GLS-010" OR ABSTRACT:"GLS-010" OR TITLE:"AB122" OR ABSTRACT:"AB122") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Zimberelimab, not a curated reading list.
Similar pages
not linked directly; found by shared links- TreatmentDomvanalimab
Shares Study of Novel Treatment Combination Therapies in Participants With Head and Neck Squamous Cell Carcinoma Regardless of PD-L1 Expression Status; Subst, Study With Various Immunotherapy Treatments in Participants With Lung Cancer, Study Evaluating Effectiveness and Safety of Zimberelimab and Domvanalimab in Lung Cancer, Study of Novel Treatment Combinations in Patients With Lung Cancer and the tag pipeline.
- TreatmentQuemliclustat
Shares Study With Various Immunotherapy Treatments in Participants With Lung Cancer and the tag pipeline.
- TreatmentSocazolimab
Shares Cervical cancer, Immune checkpoint inhibitors and the tag pipeline.
- TreatmentLorigerlimab
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- TreatmentFavezelimab
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- TreatmentPucotenlimab
Shares PD-1, Immune checkpoint inhibitors and the tag pipeline.
- TreatmentSSGJ-705
Shares PD-1 and the tag pipeline.
- TreatmentCD19 t-haNK
Shares Hodgkin lymphoma and the tag pipeline.