OnCo
ideasIdea

Offline decision support for generalists treating common cancers in low-resource settings

A phone app that works without internet and guides a general doctor or nurse through diagnosing and treating common cancers with the drugs actually available locally.

In much of the world cancer is treated by generalists with no oncologist within reach. Resource-stratified guidelines (NCCN Harmonized Guidelines for sub-Saharan Africa, ASCO resource-stratified guidelines, WHO essential medicines) exist as documents. Encoding them as offline-capable, computable decision support with local formulary awareness, dose calculators and referral criteria, endorsed by WHO and ministries, would put them at the point of care.

Hypothesis
Generalists using offline decision support will deliver guideline-concordant treatment in a substantially higher share of cases and reduce serious dosing errors versus usual practice.
Rationale
Offline clinical decision support for HIV and maternal health improved adherence to protocols in LMIC trials; cancer guidance is more complex but the delivery mechanism is proven.
What would test it
Cluster-randomise 20 district hospitals in two countries to the app or usual care for breast and cervical cancer; measure concordance and dosing errors over 12 months.
Maturity
early clinical
Who has to act
philanthropy
Cost to try
Medium ($1M to $50M)
Years to first evidence
3
Bottlenecks it attacks

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