Validate real-world progression against central imaging review
Real-world studies say a drug 'stopped working' based on clinic notes. Check how often that matches a proper scan review, and fix the definitions so the two agree.
Real-world PFS (rwPFS) and real-world response are derived from clinician notes and imaging reports, with definitions that differ by vendor. Concordance with RECIST-based central review is only moderately studied. The proposal is a programme in which a sample of real-world progression events in federated datasets is re-read by blinded central radiology, error rates are published by cancer type and data source, and a harmonised definition with known operating characteristics is adopted by regulators.
- Weak real-world evidence and registries · We do not reliably know what happens to patients after approval, so we cannot tell which drugs deliver in practice.
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not linked directly; found by shared links- IdeaValidate real-world progression endpoints so pragmatic trials can use them
Shares RECIST, Weak real-world evidence and registries, Real-world evidence, Progression-free survival (PFS).
- IdeaOpen, benchmarked algorithms for lines of therapy and progression from routine data
Shares Weak real-world evidence and registries, Real-world evidence, Progression-free survival (PFS).
- IdeaA global federated real-world evidence network at regulatory grade
Shares Tempus AI, Weak real-world evidence and registries, Real-world evidence.
- IdeaWatch routine care for drug combinations that quietly make cancer treatment worse
Shares Tempus AI, Weak real-world evidence and registries, Real-world evidence.
- IdeaEmulate combination trials from real-world data to triage which ones to run
Shares Tempus AI, Weak real-world evidence and registries, Real-world evidence.
- IdeaStructured, coded radiology reports for cancer response instead of free text
Shares RECIST, Weak real-world evidence and registries, Progression-free survival (PFS).
- IdeaLinked prescribing and outcome data to find drug interactions with cancer therapy
Shares Weak real-world evidence and registries, Real-world evidence.
- IdeaWearable activity data as a validated real-world endpoint
Shares Weak real-world evidence and registries, Real-world evidence.