An annual map of high-burden questions that nobody is funding
Mine grant databases and the literature to find cancer types and questions with heavy burden and zero active projects, then publish the list so funders and scientists can go there.
Cross the burden matrix (cancer type by stage by question: prevention, detection, metastasis, resistance, supportive care) against active grants, registered trials and recent publications to identify 'white space': cells with high burden and little or no activity. Publish a ranked list each year with suggested first experiments, and pair it with a dedicated call. Language models can classify grant abstracts and trial registrations at scale, which makes the map cheap to maintain.
- Funding follows fashion, not burden · Money goes to the cancers and questions that are easy or popular, not the ones that kill most or where a dollar would do most.
- Failures are hidden · Negative trials, failed drugs and abandoned programmes are rarely published, so the same mistakes are repeated.
Pages like this
not linked directly; found by shared links- IdeaStop failing trials earlier with pre-registered aggressive futility rules
Shares ClinicalTrials.gov, Failures are hidden, Funding follows fashion, not burden.
- IdeaAutomatically detect when a trial changes its outcomes after the fact
Shares PubMed & Europe PMC, ClinicalTrials.gov, Failures are hidden.
- IdeaMandatory machine-readable portfolio reporting for all large cancer funders
Shares A public dashboard of research money per death for every cancer, Funding follows fashion, not burden.
- IdeaNo new trial approval until the sponsor has reported its old ones
Shares ClinicalTrials.gov, Failures are hidden.
- IdeaA target de-risking index that counts failures as well as successes
Shares Open Targets Platform, Failures are hidden.
- IdeaAn open forecasting tournament on which combination trials will succeed
Shares ClinicalTrials.gov, Funding follows fashion, not burden.
- IdeaA public transparency score for every trial sponsor, used by sites and patients
Shares ClinicalTrials.gov, Failures are hidden.
- IdeaA registry for preclinical experiments that did not work
Shares Open Targets Platform, PubMed & Europe PMC, Failures are hidden.