Taking and holding a deep breath during each beam moves the heart away from the treated breast and roughly halves the dose it receives. England's national guideline has recommended it for left-sided breast cancer since 2018, yet surveys in Germany, Austria, Switzerland, Australia and the United States found it applied to a fraction of the people who could have it.
Why heart dose matters. In a population-based study of 2,168 women treated between 1958 and 2001 in Sweden and Denmark, the rate of major coronary events rose by 7.4 per cent for every gray of mean dose to the heart (95 per cent confidence interval 2.9 to 14.5), with no threshold below which the risk disappeared, starting within five years and continuing into the third decade. The proportional increase was the same in women with and without cardiac risk factors, so women who already had those factors gained the most in absolute terms from a lower dose.
What breath-hold does. A pooled analysis of 12 comparative studies with 1,019 patients found that breath-hold lowered heart dose, dose to the left anterior descending coronary artery and left lung dose compared with free breathing, without reducing coverage of the breast. A planning study using audio coaching and visual feedback reduced mean heart dose from 3.7 to 1.7 Gy and mean coronary artery dose from 18.1 to 6.4 Gy. The UK HeartSpare study randomised 23 women between a voluntary breath-hold and one held by a device that closes a valve: dose and positional accuracy were the same, patients and radiographers preferred the voluntary version, it was quicker to set up, and it was cheaper. The voluntary technique needs no new machine.
The guideline. NICE recommendation 1.13.2 in NG101 (2018) reads: "Use a deep inspiratory breath-hold radiotherapy technique for people with left-sided breast cancer to reduce the dose to the heart." The committee found no harms and no loss of target coverage, and found no evidence either way for right-sided cancer, so it made no recommendation there.
The measured gap. A 2015 survey of 82 radiotherapy departments in Germany, Austria and German-speaking Switzerland found that 90.2 per cent offered a heart-sparing technique, but 87.7 per cent used one in fewer than half of their breast cancer patients, and fewer than half (46.3 per cent) had written internal guidance. A survey of 50 of Australia's 69 radiotherapy centres in the same year concluded there may be less uptake of breath-hold there than in the international literature. A 2022 survey of 53 United States radiation oncologists found 90 per cent offered breath-hold and 74 per cent of those used it for at least a quarter of their breast patients; 32 per cent said they would be less likely to use it for a patient who did not speak English. No source OnCo found measures breath-hold use across the NHS.
What a reader can do: anyone having radiotherapy to the left breast or chest wall can ask whether breath-hold is planned for them and, if not, why not.
Shares Radiotherapy set-up without permanent ink tattoos, using surface guidance or invisible ink, Knowledge reaches practice too slowly, Toxicity and quality of life are undervalued, Breast cancer (all types) and the tags protocol-upgrade, upgrade:proven-unevenly-used, breast.
Shares National Institute for Health and Care Excellence, Knowledge reaches practice too slowly, Breast cancer (all types), HR-positive / HER2-negative breast cancer and the tags protocol-upgrade, upgrade:proven-unevenly-used, breast.
Shares Knowledge reaches practice too slowly, Toxicity and quality of life are undervalued and the tags protocol-upgrade, upgrade:proven-unevenly-used, precision.
Shares Toxicity and quality of life are undervalued and the tags protocol-upgrade, upgrade:proven-unevenly-used, precision.
Shares Toxicity and quality of life are undervalued and the tags protocol-upgrade, upgrade:proven-unevenly-used, precision.
Shares Surface-guided radiotherapy (SGRT), Deep inspiration breath-hold (DIBH), Respiratory motion management (4D-CT, gating, breath-hold, tracking), HER2-positive breast cancer and the tag precision.
Shares Knowledge reaches practice too slowly, Toxicity and quality of life are undervalued, Breast cancer (all types) and the tags protocol-upgrade, upgrade:proven-unevenly-used.
Shares National Institute for Health and Care Excellence, Toxicity and quality of life are undervalued, HR-positive / HER2-negative breast cancer and the tags protocol-upgrade, upgrade:proven-unevenly-used.
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