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A reported prevalence of 0 to 84 per cent for the same late effect is a measurement failure. Core outcome sets are cheap, need no new biology, and would unlock the studies the field has already paid for.
This is the least glamorous and probably the highest-return item on this agenda. Across this front, studies exist and cannot be combined: kidney impairment after childhood cancer is reported between 0 and 84 per cent with no agreed outcome measure; nail changes after chemotherapy between 0 and 44 per cent; time to diagnosis in adolescents and young adults could not be meta-analysed at all because the distributions were incomparable; quality of life after a stoma or limb loss was measured inconsistently with scores varying substantially; fear of recurrence, the most reported unmet need in survivorship, still lacks consensus definitions and well-validated measures by its own field's assessment.
A core outcome set specifies a minimum set of outcomes and the instrument for each, agreed by a structured consensus process including patients. It does not stop anyone measuring more. It costs a fraction of a single trial, and it changes what a decade of subsequent studies can be used for. The methodology is established in other fields and has been applied in oncology for specific tumour types.
The lever is not persuasion but funding and publication. A funder that requires the relevant core outcome set in any survivorship application, and a journal that requires it to be reported, changes practice faster than consensus alone.
Shares Give survivorship interventions a shared control arm, Recovery and rejuvenation roadmap: cure is not enough → survivorship gets a name → the cohorts that measured the cost → exercise proven as treatment → biological ageing measured and sold → repair, if anyone funds it and the tags rejuvenation, survivorship, open-problem.
Shares No treatment restores the thinking that cancer treatment takes, Recovery and rejuvenation roadmap: cure is not enough → survivorship gets a name → the cohorts that measured the cost → exercise proven as treatment → biological ageing measured and sold → repair, if anyone funds it and the tags rejuvenation, survivorship, open-problem.
Shares Recovery and rejuvenation roadmap: cure is not enough → survivorship gets a name → the cohorts that measured the cost → exercise proven as treatment → biological ageing measured and sold → repair, if anyone funds it and the tags rejuvenation, survivorship, open-problem.
Shares The field cannot pool its own studies, because it has not agreed what to measure, Toxicity and quality of life are undervalued and the tags rejuvenation, survivorship.
Shares Recovery and rejuvenation roadmap: cure is not enough → survivorship gets a name → the cohorts that measured the cost → exercise proven as treatment → biological ageing measured and sold → repair, if anyone funds it and the tags rejuvenation, survivorship, open-problem.
Shares Recovery and rejuvenation roadmap: cure is not enough → survivorship gets a name → the cohorts that measured the cost → exercise proven as treatment → biological ageing measured and sold → repair, if anyone funds it and the tags rejuvenation, survivorship, open-problem.
Shares International Guideline Harmonization Group for late effects of childhood cancer, Recovery and rejuvenation roadmap: cure is not enough → survivorship gets a name → the cohorts that measured the cost → exercise proven as treatment → biological ageing measured and sold → repair, if anyone funds it and the tags rejuvenation, survivorship, open-problem.
Shares Recovery and rejuvenation roadmap: cure is not enough → survivorship gets a name → the cohorts that measured the cost → exercise proven as treatment → biological ageing measured and sold → repair, if anyone funds it and the tags rejuvenation, survivorship, open-problem.