A non-profit phase 1b combination unit that any drug owner can use
Build a shared, not-for-profit clinical unit that runs early combination trials to a standard recipe, so that small companies and academics can test pairs without building their own trial machinery.
Early combination trials repeat the same work: pharmacokinetic interaction, overlapping toxicity, dose finding. A utility unit with standard protocols, pre-negotiated site contracts and a fixed price per arm (analogous to a contract research organisation but mission-driven and data-open) would lower the barrier for combinations that no single company will sponsor, especially those pairing drugs from different owners.
- Too many combinations to test · There are thousands of possible drug pairs and sequences. Trials can test a few dozen a year.
- The valley of death between lab and product · Most academic discoveries die before anyone tests them in people because nobody funds the middle step.
Pages like this
not linked directly; found by shared links- InstitutionWorldwide Cancer Research
Shares The valley of death between lab and product, Cancer Research UK.
- PersonUwe Oelfke
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Shares The Institute of Cancer Research, The Royal Marsden, Too many combinations to test.
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Shares The valley of death between lab and product, Cancer Research UK.
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