Hotspot activating PRKD1 somatic mutations in polymorphous low-grade adenocarcinomas of the salivary glands
Paper by Anthony C. Nichols indexed on Europe PMC as PubMed record 25240283, in Nature Genetics (2014), one of the most cited records naming an author with this name at Verspeeten Family Cancer Centre, London Health Sciences Centre.
Overview
Polymorphous low-grade adenocarcinoma (PLGA) is the second most frequent type of malignant tumor of the minor salivary glands. We identified PRKD1 hotspot mutations encoding p.Glu710Asp in 72.9% of PLGAs but not in other salivary gland tumors. Functional studies demonstrated that this kinase-activating alteration likely constitutes a driver of PLGA.
Indexed on Europe PMC as PubMed record 25240283 (DOI 10.1038/ng.3096). Its author list gives "Nichols AC" with the affiliation "Western University, London, Ontario, Canada", which names Verspeeten Family Cancer Centre, London Health Sciences Centre; that is how the record was matched to Anthony C. Nichols, and no figure has been checked by an editor.
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