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An international panel simplified precursor grading to low grade and high grade, reserving high grade for carcinoma in situ, and set rules for margins, small intraductal lesions and simple mucinous cysts.
International experts revised the 2004 recommendations for assessing and reporting precursor lesions of the pancreas, including PanIN, IPMN, mucinous cystic neoplasm and others. A two-tiered system (low versus high grade) is proposed for all precursor lesions, with former PanIN-2 and intermediate-grade neoplasms categorised as low grade and high-grade dysplasia reserved for carcinoma in situ-type lesions. PanIN of any grade at a resection margin has no prognostic implication. Intraductal lesions of 0.5 to 1 cm may be large PanINs or small IPMNs, with 'incipient IPMN' reserved for those with intestinal or oncocytic papillae or GNAS mutations. Distance between IPMN and invasive carcinoma should be measured to assess concomitant versus associated status. 'Intraductal spread of invasive carcinoma' and 'simple mucinous cyst' are defined.
The reporting standard behind every modern precursor study and the reason a pathology report now says low or high grade rather than PanIN-2.
Shares Intraductal papillary mucinous neoplasm and other pancreatic cystic precursors, Johns Hopkins Hospital / Sidney Kimmel Comprehensive Cancer Center, Pancreatic ductal adenocarcinoma.
Shares Intraductal papillary mucinous neoplasm and other pancreatic cystic precursors, Johns Hopkins Hospital / Sidney Kimmel Comprehensive Cancer Center, Memorial Sloan Kettering Cancer Center, Pancreatic ductal adenocarcinoma.
Shares GNAS, Intraductal papillary mucinous neoplasm and other pancreatic cystic precursors, Johns Hopkins Hospital / Sidney Kimmel Comprehensive Cancer Center, Pancreatic ductal adenocarcinoma.
Shares Intraductal papillary mucinous neoplasm and other pancreatic cystic precursors, Pancreatic ductal adenocarcinoma.
Shares Intraductal papillary mucinous neoplasm and other pancreatic cystic precursors, Pancreatic ductal adenocarcinoma.
Shares Intraductal papillary mucinous neoplasm and other pancreatic cystic precursors, Pancreatic ductal adenocarcinoma.
Shares GNAS, Intraductal papillary mucinous neoplasm and other pancreatic cystic precursors, Johns Hopkins Hospital / Sidney Kimmel Comprehensive Cancer Center, Pancreatic ductal adenocarcinoma.
Shares GNAS, Intraductal papillary mucinous neoplasm and other pancreatic cystic precursors, Johns Hopkins Hospital / Sidney Kimmel Comprehensive Cancer Center, Pancreatic ductal adenocarcinoma.