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Sequencing the fluid from pancreatic cysts found that two-thirds of the mucinous kind carry a mutation at one spot in the GNAS gene, and the same mutation turns up in the cancers that grow out of them, giving a marker for which cyst is which.
DNA from IPMN cyst fluids of 19 patients was searched for mutations in 169 cancer genes. Besides the expected KRAS mutations, recurrent mutations at codon 201 of GNAS were identified; 113 further IPMNs were analysed, giving GNAS mutations in 66% and KRAS or GNAS in 96%. In seven of eight invasive adenocarcinomas arising with GNAS-mutant IPMNs, the same GNAS mutation was present in the invasive lesion. GNAS mutations were not found in other cystic neoplasms of the pancreas or in invasive adenocarcinomas unassociated with IPMN.
A GNAS mutation in cyst fluid says the cyst is an IPMN, and in a cancer it says the cancer came from one, which is the molecular basis of cyst triage.
Shares Anirban Maitra, GNAS, Bert Vogelstein, Intraductal papillary mucinous neoplasm and other pancreatic cystic precursors.
Shares Biopsy, Luis A. Diaz Jr., GNAS, Bert Vogelstein.
Shares Biopsy, Intraductal papillary mucinous neoplasm and other pancreatic cystic precursors, Johns Hopkins Hospital / Sidney Kimmel Comprehensive Cancer Center, Pancreatic ductal adenocarcinoma.
Shares GNAS, Intraductal papillary mucinous neoplasm and other pancreatic cystic precursors, Johns Hopkins Hospital / Sidney Kimmel Comprehensive Cancer Center, Pancreatic ductal adenocarcinoma.
Shares GNAS, Intraductal papillary mucinous neoplasm and other pancreatic cystic precursors, Johns Hopkins Hospital / Sidney Kimmel Comprehensive Cancer Center, KRAS.
Shares GNAS, Intraductal papillary mucinous neoplasm and other pancreatic cystic precursors, KRAS, Pancreatic ductal adenocarcinoma.
Shares Anirban Maitra, Bert Vogelstein, Johns Hopkins Hospital / Sidney Kimmel Comprehensive Cancer Center, KRAS.
Shares Bert Vogelstein, Intraductal papillary mucinous neoplasm and other pancreatic cystic precursors, Johns Hopkins Hospital / Sidney Kimmel Comprehensive Cancer Center, Pancreatic ductal adenocarcinoma.