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CancerSEEK, a blood test reading eight proteins and mutations in free DNA, found a median 70% of 1,005 non-spread cancers of eight types, including pancreatic cancer, and pointed to the organ involved in most cases.
A blood test assessing circulating protein levels and mutations in cell-free DNA was applied to 1,005 patients with non-metastatic, clinically detected cancers of the ovary, liver, stomach, pancreas, oesophagus, colorectum, lung or breast. CancerSEEK tests were positive in a median of 70% of the eight cancer types, with sensitivities of 69 to 98% for the five types with no screening test for average-risk individuals (ovary, liver, stomach, pancreas, oesophagus). Specificity exceeded 99% with 7 of 812 healthy controls positive, and the test localised the cancer to a small number of anatomical sites in a median 83% of patients.
The proof of principle for multi-cancer blood tests that include pancreas; the sensitivity figures come from known cancers, not from screening.
Shares Nickolas Papadopoulos, DETECT-A: a blood test plus PET-CT to screen 10,006 women with no symptoms, Kenneth W. Kinzler, Cell-free DNA (cfDNA).
Shares Nickolas Papadopoulos, Cell-free DNA (cfDNA), Bert Vogelstein, Proteomics & phosphoproteomics.
Shares Nickolas Papadopoulos, Kenneth W. Kinzler, Bert Vogelstein, Science.
Shares Kenneth W. Kinzler, Bert Vogelstein, Johns Hopkins Hospital / Sidney Kimmel Comprehensive Cancer Center, Pancreatic ductal adenocarcinoma.
Shares Kenneth W. Kinzler, Bert Vogelstein, Johns Hopkins Hospital / Sidney Kimmel Comprehensive Cancer Center, Pancreatic ductal adenocarcinoma.
Shares DETECT-A: a blood test plus PET-CT to screen 10,006 women with no symptoms, Cell-free DNA (cfDNA), Multi-cancer early detection (MCED), Pancreatic ductal adenocarcinoma.
Shares Cell-free DNA (cfDNA), Multi-cancer early detection (MCED), Circulating tumour DNA (ctDNA), Liquid biopsy (ctDNA).
Shares Cell-free DNA (cfDNA), Johns Hopkins Hospital / Sidney Kimmel Comprehensive Cancer Center, Circulating tumour DNA (ctDNA), Liquid biopsy (ctDNA).