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The European oncology society's 2023 guideline for bowel cancer that has spread, covering which tests every patient needs, how to choose the first combination of drugs, when to operate on liver secondaries and how to follow patients up.
ESMO Clinical Practice Guideline for metastatic colorectal cancer, published in Annals of Oncology in 2023 by Cervantes, Adam, Roselló, Arnold, Normanno, Taïeb, Seligmann, De Baere, Osterlund, Yoshino and Martinelli for the ESMO Guidelines Committee. Europe PMC indexes no abstract for this article, so OnCo carries no figures from it; the guideline itself is open on the ESMO website and is maintained as a living document there.
It is the document that fixes the molecular work-up OnCo's colorectal pages assume: RAS and BRAF status, mismatch repair or microsatellite instability status, and HER2 on every patient with metastatic disease, with primary tumour sidedness used alongside RAS status to choose between an EGFR antibody and bevacizumab.
This is the European standard the UK and NHS page for colorectal cancer is compared against; NICE NG151 covers the same ground for England with a narrower set of funded drugs.
Shares Josep Tabernero, ESMO Clinical Practice Guidelines & MCBS, European Society for Medical Oncology (ESMO), Annals of Oncology and the tag colorectal-evidence.
Shares Andrés Cervantes, ESMO Clinical Practice Guidelines & MCBS, European Society for Medical Oncology (ESMO), Annals of Oncology and the tag colorectal-evidence.
Shares KEYNOTE-177, Eric Van Cutsem, Microsatellite instability (MSI-H) / mismatch repair deficiency (dMMR), Colorectal cancer and the tag colorectal-evidence.
Shares Josep Tabernero, Prognostic and predictive value of primary tumour side in patients with RAS wild-type metastatic colorectal cancer treated with chemotherapy and EGFR directed antibodies in six randomized trials, Sidedness (left vs right colon), Colorectal cancer and the tag colorectal-evidence.
Shares Josep Tabernero, BEACON CRC, Eric Van Cutsem, Colorectal cancer and the tag colorectal-evidence.
Shares Josep Tabernero, Eric Van Cutsem, Colorectal cancer and the tag colorectal-evidence.
Shares Josep Tabernero, Eric Van Cutsem, Colorectal cancer and the tag colorectal-evidence.
Shares Prognostic and predictive value of primary tumour side in patients with RAS wild-type metastatic colorectal cancer treated with chemotherapy and EGFR directed antibodies in six randomized trials, Sidedness (left vs right colon), Colorectal cancer and the tag colorectal-evidence.