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A review of every attempt to attack the tissue around pancreatic cancer, explaining why deconstructing the scar tissue and blocking single immune-suppressing pathways failed and what multi-target approaches are being tried instead.
Metastatic pancreatic ductal adenocarcinoma remains one of the most lethal solid tumours despite multi-agent chemotherapy. Efforts to exploit the tumour microenvironment by deconstructing the desmoplastic stroma and targeting immunosuppressive pathways have largely failed; evidence now shows the stroma is multi-faceted, illustrating the complexity of targeting isolated features. The review describes how the microenvironment has been targeted, notes clinical outcomes that unexpectedly contradicted preclinical observations, and considers multi-modal approaches and biologically integrated targets aimed at remodelling it.
The reference for why pancreatic microenvironment trials read as a list of failures and what the field now means by remodelling rather than removing the stroma.
Shares Elizabeth M. Jaffee, Fibroblast activation, desmoplasia & matrix stiffness, Tumour microenvironment (TME), Pancreatic ductal adenocarcinoma.
Shares Desmoplasia (tumour stroma), Fibroblast activation, desmoplasia & matrix stiffness, Tumour microenvironment (TME), Hot vs cold tumours.
Shares Desmoplasia (tumour stroma), Fibroblast activation, desmoplasia & matrix stiffness, Tumour microenvironment (TME), Pancreatic ductal adenocarcinoma.
Shares Desmoplasia (tumour stroma), Fibroblast activation, desmoplasia & matrix stiffness, Tumour microenvironment (TME), Pancreatic ductal adenocarcinoma.
Shares Desmoplasia (tumour stroma), Fibroblast activation, desmoplasia & matrix stiffness, Tumour microenvironment (TME), Pancreatic ductal adenocarcinoma.
Shares Desmoplasia (tumour stroma), Fibroblast activation, desmoplasia & matrix stiffness, Tumour microenvironment (TME), Hot vs cold tumours.
Shares Desmoplasia (tumour stroma), Fibroblast activation, desmoplasia & matrix stiffness, Pancreatic ductal adenocarcinoma.
Shares Myeloid suppression: TAMs, MDSCs & don't-eat-me signals, Fibroblast activation, desmoplasia & matrix stiffness, Tumour microenvironment (TME), Hot vs cold tumours.