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Reading pancreatic tumours one cell at a time confirmed the two known fibroblast types and found a third that carries the molecules used to show antigens to immune cells and can switch on helper T cells.
Single-cell RNA sequencing characterised the neoplastic and microenvironment content of human and mouse pancreatic tumours. Myofibroblastic and inflammatory CAFs were corroborated and their in vivo gene signatures defined. A new CAF population expressing MHC class II and CD74 but not classic costimulatory molecules was described and termed antigen-presenting CAFs; they activated CD4-positive T cells in an antigen-specific fashion in a model system, confirming an immune-modulatory capacity.
Fibroblasts are part of the immune conversation, not just a physical barrier, which is why stromal and immune strategies are now designed together.
Shares Fibroblast subtypes in the pancreatic cancer stroma (myCAF, iCAF and apCAF), David A. Tuveson, Cold Spring Harbor Laboratory, Fibroblast activation, desmoplasia & matrix stiffness.
Shares Fibroblast subtypes in the pancreatic cancer stroma (myCAF, iCAF and apCAF), Fibroblast activation, desmoplasia & matrix stiffness, Tumour microenvironment (TME), Single-cell & spatial profiling.
Shares Elizabeth M. Jaffee, Fibroblast activation, desmoplasia & matrix stiffness, Tumour microenvironment (TME), Pancreatic ductal adenocarcinoma.
Shares David A. Tuveson, Fibroblast activation, desmoplasia & matrix stiffness, Pancreatic ductal adenocarcinoma.
Shares Fibroblast activation, desmoplasia & matrix stiffness, Tumour microenvironment (TME), Pancreatic ductal adenocarcinoma.
Shares David A. Tuveson, Cold Spring Harbor Laboratory, Single-cell & spatial profiling, Pancreatic ductal adenocarcinoma.
Shares Fibroblast activation, desmoplasia & matrix stiffness, Single-cell & spatial profiling, Pancreatic ductal adenocarcinoma.