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RNA sequencing of triple-negative tumours from African Americans, West Africans and East Africans, with ancestry measured genetically rather than self-reported, found hundreds of genes tied to African ancestry and a distinct immune landscape in the tumours.
RNA sequencing was performed on an international cohort of African Americans and West and East Africans with TNBC, with comprehensive genetic ancestry estimation. Expression of 613 genes was associated with African ancestry and more than 2,000 with regional African ancestry; a subset also differed in normal breast tissue. Pathway enrichment and deconvolution of tumour cellular composition revealed distinct tumour-associated immunological profiles in patients of African descent.
It replaces self-reported race with measured ancestry and shows the immune microenvironment of TNBC differs with it, a variable immunotherapy trials have not stratified on.
Shares Cancer Discovery, Triple-negative breast cancer (TNBC).
Shares Tumour microenvironment (TME), Triple-negative breast cancer (TNBC).
Shares Tumour microenvironment (TME), Triple-negative breast cancer (TNBC).
Shares Tumour microenvironment (TME), Triple-negative breast cancer (TNBC).