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A lung cancer study that read EGFR mutations from vesicle RNA and cell-free DNA together, finding more mutations than from DNA alone, most of all in patients whose cancer sheds little.
In 84 patients, sensitivity was 98 per cent for activating EGFR mutations and 90 per cent for T790M with combined exosomal RNA and cell-free DNA, against 82 and 84 per cent for circulating tumour DNA by BEAMing. In patients with intrathoracic disease (M0/M1a, 21 patients), sensitivity rose from 26 to 74 per cent for activating mutations (P = 0.003) and from 19 to 31 per cent for T790M (P = 0.5).
The clearest measured case that RNA from the same blood draw adds tumour signal where DNA runs short, though in advanced disease far above residual disease levels.
Shares Read tumour RNA and tumour DNA from the same blood draw to find and type residual cancer, Liquid RNA biopsy (cell-free, vesicle and platelet RNA), Circulating tumour DNA (ctDNA), Liquid biopsy (ctDNA).
Shares Read tumour RNA and tumour DNA from the same blood draw to find and type residual cancer, Liquid RNA biopsy (cell-free, vesicle and platelet RNA), Naming which clone or phenotype is left after treatment, Liquid biopsy (ctDNA).
Shares Read tumour RNA and tumour DNA from the same blood draw to find and type residual cancer, Liquid RNA biopsy (cell-free, vesicle and platelet RNA), Naming which clone or phenotype is left after treatment.
Shares Naming which clone or phenotype is left after treatment, Circulating tumour DNA (ctDNA), Liquid biopsy (ctDNA).
Shares Read tumour RNA and tumour DNA from the same blood draw to find and type residual cancer, Liquid RNA biopsy (cell-free, vesicle and platelet RNA), Naming which clone or phenotype is left after treatment.
Shares Read tumour RNA and tumour DNA from the same blood draw to find and type residual cancer, Liquid RNA biopsy (cell-free, vesicle and platelet RNA).
Shares Read tumour RNA and tumour DNA from the same blood draw to find and type residual cancer, Liquid RNA biopsy (cell-free, vesicle and platelet RNA).
Shares Read tumour RNA and tumour DNA from the same blood draw to find and type residual cancer, Liquid RNA biopsy (cell-free, vesicle and platelet RNA).
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