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Following more than 200,000 twins in Denmark, Finland, Norway and Sweden for a median of 32 years, this study estimated that about a third of the variation in cancer risk is inherited, with higher shares for melanoma and prostate cancer.
A prospective cohort of 80,309 identical and 123,382 same-sex fraternal twin individuals in the population-based twin registers of Denmark, Finland, Norway and Sweden, followed through the cancer registers between 1943 and 2010. Time-to-event models estimated familial risk, the risk of cancer given that a co-twin developed it, and heritability, adjusting for age and follow-up and accounting for censoring and the competing risk of death. Karolinska Institutet's Department of Medical Epidemiology and Biostatistics was among the collaborating centres.
It gives patients and counsellors population figures for how much a twin's or close relative's cancer raises one's own risk, cancer by cancer, and it shows that for prostate cancer and melanoma inherited risk is substantial.
Shares Environmental and heritable factors in the causation of cancer: analyses of cohorts of twins from Sweden, Denmark, and Finland, Karolinska University Hospital, Inherited risk is mostly unidentified, Prostate cancer.
Shares JAMA, Prostate cancer.
Shares JAMA, Prostate cancer.
Shares Karolinska University Hospital, Melanoma, Prostate cancer.
Shares Inherited risk is mostly unidentified, Prostate cancer.
Shares Inherited risk is mostly unidentified, Melanoma, Prostate cancer.
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