Preneoplastic lesions and gallbladder cancer: an estimate of the period required for progression
Comparing the ages of Chilean patients with dysplasia, early cancer, advanced cancer and spread cancer of the gallbladder, the authors estimated that it takes around 15 years to go from dysplasia to advanced disease.
Overview
84 cases of dysplasia, 60 early carcinomas, 181 advanced carcinomas and 121 metastatic gallbladder cancers were analysed using age as the main parameter, with analysis of variance and multiple regression. Women were younger than men across all lesions, and mean age differed by lesion type: 46.3 years (SD 16) for dysplasia, 57.5 (16.7) for early carcinoma, 59 (13.7) for advanced carcinoma and 61.1 (12.1) for metastatic disease.
Multiple regression showed a significant difference in mean age between dysplastic and carcinoma groups (r = 0.386; P < 0.001). The period required to progress from dysplasia to advanced carcinoma was estimated at around 15 years, with a continuum in the progression of the lesions.
- Mean ages: dysplasia 46.3, early carcinoma 57.5, advanced carcinoma 59, metastatic 61.1 years.
- Estimated 15 years from dysplasia to advanced carcinoma.
- Women younger than men at every stage.
The origin of the 10 to 15 year window quoted for gallbladder carcinogenesis, which is the argument that cholecystectomy for stones or dysplasia in high-incidence regions prevents cancer years later.
- Cross-sectional age comparison, not longitudinal follow-up.
- Chilean population with high incidence and early onset.
Similar pages
not linked directly; found by shared links- Key paperGenomic characterization of co-existing neoplasia and carcinoma lesions reveals distinct evolutionary paths of gallbladder cancer
Shares Metaplasia, dysplasia, carcinoma in situ: the flat route to gallbladder cancer, Dysplasia (pre-cancerous change), Gallbladder cancer.
- Key paperPreneoplastic lesions in gallbladder cancer
Shares Metaplasia, dysplasia, carcinoma in situ: the flat route to gallbladder cancer, Dysplasia (pre-cancerous change), Gallbladder cancer.
- TermIntracholecystic papillary-tubular neoplasm (ICPN)
Shares Metaplasia, dysplasia, carcinoma in situ: the flat route to gallbladder cancer, Dysplasia (pre-cancerous change), Gallbladder cancer.
- Key paperIntracholecystic papillary-tubular neoplasms (ICPN) of the gallbladder (neoplastic polyps, adenomas, and papillary neoplasms that are at least 1.0 cm): clinicopathologic and immunohistochemical analysis of 123 cases
Shares Dysplasia (pre-cancerous change), Gallbladder cancer.
- TargetCTNNB1
Shares Metaplasia, dysplasia, carcinoma in situ: the flat route to gallbladder cancer, Gallbladder cancer.
- TermCarcinoma in situ (CIS)
Shares Dysplasia (pre-cancerous change), Gallbladder cancer.
- CancerCarcinoma in situ and dysplasia of the gallbladder
Shares Dysplasia (pre-cancerous change), Gallbladder cancer.