Macrophage IL-10 blocks CD8+ T cell-dependent responses to chemotherapy by suppressing IL-12 expression in intratumoral dendritic cells
Paper by E. Shelley Hwang indexed on Europe PMC as PubMed record 25446896, in Cancer Cell (2014), one of the most cited records naming an author with this name at Duke Cancer Institute.
Overview
Blockade of colony-stimulating factor-1 (CSF-1) limits macrophage infiltration and improves response of mammary carcinomas to chemotherapy. Herein we identify interleukin (IL)-10 expression by macrophages as the critical mediator of this phenotype. Infiltrating macrophages were the primary source of IL-10 within tumors, and therapeutic blockade of IL-10 receptor (IL-10R) was equivalent to CSF-1 neutralization in enhancing primary tumor response to paclitaxel and carboplatin. Improved response to chemotherapy was CD8(+) T cell-dependent, but IL-10 did not directly suppress CD8(+) T cells or alter macrophage polarization. Instead, IL-10R blockade increased intratumoral dendritic cell expression of IL-12, which was necessary for improved outcomes. In human breast cancer, expression of IL12A and cytotoxic effector molecules were predictive of pathological complete response rates to paclitaxel.
Indexed on Europe PMC as PubMed record 25446896 (DOI 10.1016/j.ccell.2014.09.006). Its author list gives "Hwang ES" with the affiliation "Surgery Department, Duke University, Durham, NC 27708, USA", which names Duke Cancer Institute; that is how the record was matched to E. Shelley Hwang, and no figure has been checked by an editor.
One of the most cited papers Europe PMC returns for E. Shelley Hwang at Duke Cancer Institute, so it is a natural starting point for reading their work. The record was linked automatically from the author list and affiliation; read the abstract above and the paper itself before relying on any figure.
- Matched to the person by surname, initials and an affiliation string naming the institution on the Europe PMC record; the summary reproduces the record's abstract and no figure has been verified against the full paper.
- Two authors sharing a surname, initials and institution cannot be told apart by this method; the person's profile links are the place to confirm authorship.