key papersKey paper
Phyllodes tumours of the breast: a consensus review
This international consensus review sets out how pathologists grade phyllodes tumours as benign, borderline or malignant and how those grades should guide surgery and follow-up.
Overview
Consensus review by an international group of breast pathologists on the diagnosis, grading criteria (stromal cellularity, atypia, mitoses, overgrowth and margins), differential diagnosis from fibroadenoma, molecular findings including MED12 mutations, and management implications for phyllodes tumours.
ReviewChanged practice
Authors
Tan BY, Acs G, Apple SK, et al.
Published
Histopathology, 2016
Full text
What it means
The three-tier grading on a phyllodes pathology report and the margin recommendations for each grade follow this review and the WHO classification it informed.
Caveats
- Grading remains partly subjective and inter-observer variation persists.