Gallbladder cancer: lessons from a rare tumour
A 2004 review arguing that gallbladder cancer, rare and little studied, is worth understanding because its mix of inherited risk, geography, female predominance, chronic inflammation and congenital anomalies is unusual among cancers.
Overview
Nature Reviews Cancer article stating that gallbladder cancer is a relatively rare malignancy about which knowledge is scant, and that its combination of predisposing factors (genetic predisposition, geographic distribution, female gender bias, chronic inflammation and congenital developmental abnormalities) makes it unique and informative for cancer pathogenesis generally. The authors argue that understanding how these risk factors contribute to the molecular basis of the disease is essential.
- Describes gallbladder cancer as a relatively rare malignancy about which knowledge is scant (authors' words).
Two decades on, the disease is still described as understudied in the 2025 immunogenomics literature; the reasons (rarity in the countries that fund research, incidental diagnosis, pooling with bile duct cancer in trials) have not changed.
- Review from 2004; molecular detail is dated.
- No new data.
Similar pages
not linked directly; found by shared links- Key paperGallbladder cancer
Shares A burden-to-funding audit for gallbladder cancer and a dedicated research call, Gallbladder cancer roadmap: from a chance finding at gallstone surgery to a disease with its own trials, Rare and paediatric cancers without markets, Gallbladder cancer and the tag gallbladder-evidence.
- Key paperPopulation-Specific Immunogenomic Alterations in Gallbladder Cancer and Prognostic Significance
Shares A burden-to-funding audit for gallbladder cancer and a dedicated research call, Gallbladder cancer roadmap: from a chance finding at gallstone surgery to a disease with its own trials, Rare and paediatric cancers without markets, Gallbladder cancer and the tag gallbladder-evidence.
- Key paperCarcinoma of the gallbladder: staging, treatment, and prognosis
Shares Gallbladder cancer roadmap: from a chance finding at gallstone surgery to a disease with its own trials, Gallbladder cancer and the tag gallbladder-evidence.
- Key paperSystematic review of management of incidental gallbladder cancer after cholecystectomy
Shares Gallbladder cancer roadmap: from a chance finding at gallstone surgery to a disease with its own trials, Gallbladder cancer and the tag gallbladder-evidence.
- Key paperManagement and follow-up of gallbladder polyps: updated joint guidelines between the ESGAR, EAES, EFISDS and ESGE
Shares Gallbladder cancer roadmap: from a chance finding at gallstone surgery to a disease with its own trials, Gallbladder cancer and the tag gallbladder-evidence.
- Key paperGeographic and genetic diversity in gallbladder cancer mutation profiles: insights from a worldwide exome analysis
Shares Gallbladder cancer roadmap: from a chance finding at gallstone surgery to a disease with its own trials, Gallbladder cancer and the tag gallbladder-evidence.
- Key paperIncidence of finding residual disease for incidental gallbladder carcinoma: implications for re-resection
Shares Gallbladder cancer roadmap: from a chance finding at gallstone surgery to a disease with its own trials, Gallbladder cancer and the tag gallbladder-evidence.
- Key paperEpidemiology of gallbladder cancer in India
Shares Gallbladder cancer roadmap: from a chance finding at gallstone surgery to a disease with its own trials, Gallbladder cancer and the tag gallbladder-evidence.