peoplePerson
Christopher R. Vakoc
Found that leukaemias depend on the chromatin reader BRD4, launching BET inhibitors, and mapped transcriptional addictions in sarcoma.
Identified BRD4 as a therapeutic target in AML via RNAi screening and developed CRISPR domain-scanning to find druggable protein domains; studies Ewing and rhabdomyosarcoma dependencies.
Role
Professor, CSHL Cancer Center
Institution
Specialisms
Transcriptional dependenciesBET and chromatin regulatorsCRISPR domain screens
Profiles
| Title | Journal | Year |
|---|---|---|
| RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia | Nature | 2011 |