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Living with cancer· Appointment prep

Appointment sheet: BRAF V600E-mutant colorectal cancer

One page to bring and write on: your details, the questions for BRAF V600E-mutant colorectal cancer plus your own, the words you may hear, what to bring, the treatments the standard of care names, and room for the answers and agreed next steps. What you type stays in this browser. Print it or save it as a PDF. New to all this? Start with the first 60 days. Orientation, not medical advice.

Tick the questions to print

All of this cancer's questions start ticked. Untick what does not apply; ticks are kept in this browser. .

Your own questions

Shared with the prep pack, so questions you add there appear here too.

Print or save as PDF

Use (or Ctrl+P, Cmd+P on a Mac). To keep a copy, choose Save as PDF as the destination in the print dialog. Only the sheet prints; the controls stay on screen. Your typed notes print where you typed them; empty fields print as ruled lines to write on.

Appointment sheet

BRAF V600E-mutant colorectal cancer

Prepared with OnCo (onco.cc/prep/braf-v600e-colorectal/). Orientation, not medical advice; your team knows your case.

My details

Name
Date of appointment
Hospital and clinician
Who is coming with me

What I know, what is unclear, changes to discuss

Saved in this browser
What I know so far
What is unclear to me
Changes since last time

My questions

20 on the sheet
Newly diagnosed
  1. 1.What is my exact diagnosis, stage, and grade, and which tests established them?
  2. 2.Which biomarkers have been tested on my tumour (for example BRAF V600E by sequencing or VE1 immunohistochemistry, Mismatch repair status, RAS wild-type by definition; co-mutations rare, Consensus molecular subtype 1 enrichment, Circulating tumour DNA to track MAPK reactivation on treatment), and what were the results?
  3. 3.Which subtype is my cancer, and does that change the recommended treatment?
  4. 4.Is germline (inherited) genetic testing recommended for me or my family?
Metastatic, microsatellite-stable, first line
  1. 5.For my situation (metastatic, microsatellite-stable, first line), which of the standard options do you recommend and why?
  2. 6.Am I a candidate for Encorafenib, Cetuximab, FOLFOX (5-FU, leucovorin, oxaliplatin), and what side effects should I expect?
  3. 7.How do the results of BREAKWATER apply to someone like me?
Metastatic, previously treated
  1. 8.For my situation (metastatic, previously treated), which of the standard options do you recommend and why?
  2. 9.Am I a candidate for Encorafenib, Cetuximab, Trifluridine/tipiracil or related drugs, and what side effects should I expect?
  3. 10.How do the results of BEACON CRC apply to someone like me?
Metastatic, mismatch-repair deficient
  1. 11.For my situation (metastatic, mismatch-repair deficient), which of the standard options do you recommend and why?
  2. 12.Am I a candidate for Pembrolizumab, Nivolumab, Ipilimumab, and what side effects should I expect?
  3. 13.How do the results of KEYNOTE-177 and CheckMate 8HW apply to someone like me?
Localised
  1. 14.For my situation (localised), which of the standard options do you recommend and why?
  2. 15.Am I a candidate for FOLFOX (5-FU, leucovorin, oxaliplatin), CAPOX (capecitabine, oxaliplatin), Oxaliplatin, and what side effects should I expect?
Any stage
  1. 16.Are there clinical trials I could join, for example of A Study of Encorafenib Plus Cetuximab Taken Together With Pembrolizumab Compared to Pembrolizumab Alone in People With Previously Untreated Metastatic, Efficacy and Safety of Tunlametinib Plus Vemurafenib in Patients With BRAF V600E-mutant Metastatic Colorectal Cancer, BREAKWATER, Encorafenib?
  2. 17.Would a second opinion at a high-volume centre change anything, and can you help arrange it?
  3. 18.What supportive care (symptom control, nutrition, exercise, mental health, financial help) is available from the start?
  4. 19.I read that “No standard therapy after progression on encorafenib and cetuximab”. How does that affect my plan?
  5. 20.I read that “Resistance through MAPK reactivation and MET amplification is common and untargeted”. How does that affect my plan?

The words I may hear

Tests and results to bring

Biomarker results to ask for: BRAF V600E by sequencing or VE1 immunohistochemistry, Mismatch repair status (immunotherapy if deficient), RAS wild-type by definition; co-mutations rare, Consensus molecular subtype 1 enrichment, Circulating tumour DNA to track MAPK reactivation on treatment.

Scans and tests linked to this cancer: Liquid biopsy (ctDNA).

Bring copies of scan reports, pathology and blood results, and a list of every medicine and supplement.

The treatments I may be offered

From the standard of care recorded for this cancer; which apply depends on your stage and biomarkers. Ask which the team recommends and why.

Answers and next steps

Saved in this browser
What I was told
Agreed next steps, dates and who to call