brca
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| Cancers | Other tags | ||||
|---|---|---|---|---|---|
Germline BRCA1/2 pathogenic variant (gBRCAm) BRCA1, BRCA2 A germline BRCA1 or BRCA2 variant is inherited and present in every cell, found by a blood test. It selects PARP inhibitors in breast, ovarian, pancreatic and prostate cancer and tells relatives they may carry it too. | Breast cancer, Triple-negative breast cancer, HR-positive / HER2-negative breast cancer | none | biomarker | ||
HRD-positive (genomic instability score) BRCA1, BRCA2 HRD-positive means the tumour's genome carries the scars of failed double-strand break repair (or a BRCA mutation), measured as a genomic instability score. In ovarian cancer it selects niraparib, and olaparib with bevacizumab, as first-line maintenance. | Ovarian cancer, High-grade serous ovarian cancer | none | biomarker, genome-wide | ||
Talia Golan Director, Pancreatic Cancer Center, Sheba Medical Center · Sheba Medical Center Led POLO, the first biomarker-driven trial in pancreatic cancer, which brought olaparib to BRCA carriers. | Pancreatic ductal adenocarcinoma | none | pancreatic, parp | ||
Tumour (somatic or germline) BRCA1/2 mutation and HRR gene alterations BRCA1, BRCA2 Tumour BRCA testing finds BRCA1/2 mutations in the cancer itself, whether inherited or acquired; wider panels add other repair genes such as ATM and PALB2. Ovarian and prostate cancer labels accept the tumour result for PARP inhibitors. | Ovarian cancer, High-grade serous ovarian cancer, Platinum-sensitive ovarian cancer | none | biomarker |